Clinical Studies

Warburg Hypothesis

Long-lasting improvement of physical endurance following oxygen-multistep-therapy

Increasing mental performance by multistep oxygen therapy. Computer-assisted measurements of information processing capacity, intelligence, short-term memory and further parameters of cerebral performance.

Age-dependence of oxygen transport into body tissues and the favorable modification of this transport by multistep oxygen therapy.

Control and usefulness of a capillary-wall switch mechanism in blood microcirculation. Recent results of oxygen multistep therapy research.

Results of multistep oxygen therapy in the treatment of sudden hearing loss.

Anticancer strategies to progress in tumor immunology.

General cancer prevention, metastasis prevention and the combination of classical cancer therapies with O2 multistep immunostimulation.

Hyperoxia for performance and training

Increase in the short-term memory capacity by 19-23%


Fundamentals of combating cancer metastasis by oxygen multistep immunostimulation processes. The Warburg Effect.

Oxygen Enhanced Immunostimulation processes.  

Cycling performance improved with acute exposure to hyperoxia.


Exercise training and recovery supplemented with hyperoxic gas appears to have a beneficial effect on subsequent exercise performance

Double-blind study on the long-lasting improvement of physical endurance following oxygen-multistep-therapy.


OXYGEN ENHANCED EXERCISE AND ENDURANCE. In patients with PAH/CTEPH, breathing oxygen-enriched air provides major increases in exercise performance.

Oxygen enhanced exercise improves cognitive performance and exercise tolerance.

ENERGY COST under hyperoxia influenced by reduced metabolic demands.

Hyperoxia likely restored performance due to maintenance of oxygen availability.

Nitric oxide (NO), synthesized from l‐arginine by NO synthases, plays a role in adaptation to physical exercise by modulating blood flow, muscular contraction and glucose uptake and in the control of cellular respiration.  

Hyperoxia enhances self-paced exercise performance.

Increased critical power during supine cycling.

Maximal oxygen uptake significantly improved in both groups. However, blood lactate curve during submaximal exercise test significantly improved only in the HST group.

Hyperoxia on repeated sprint cycling performance & muscle fatigue.

Hyperoxia speeds pulmonary oxygen uptake kinetics and increases critical power during supine cycling.

Dosed hypoxia-hyperoxia as a factor in improving the quality of life of elderly patients with cardiac pathology.

High-intensity interval training and hyperoxia during chemotherapy: A case report about the feasibility, safety and physical functioning in a colorectal cancer patient.

Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension.

intermittent hypoxia-hyperoxia training in coronary artery disease patients.

Aerobic efficiency is associated with the improvement in maximal power output during acute hyperoxia.

Mechanisms of Improved Exercise Performance under hyperoxia.

Hyperoxia Extends Time to Exhaustion During High-Intensity Intermittent Exercise: a Randomized, Crossover Study in Male Cyclists.

Role of CO2 in the cerebral hyperemic response to incremental normoxic and hyperoxic exercise.

Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study.

Hypoxia-hyperoxia exposure and light exercise enhances performance in athletes with overtraining syndrome: a pilot study.

Recovery effects of repeated exposures to normobaric hyperoxia on local muscle fatigue.

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